Blacks share their painful stories of bias in Orange County








It was a reign of terror that reeked of rednecks and white hoods.


Tires were slashed, rocks hurled through windows and acid pellets fired at the car of a black family, who finally fled their neighborhood in November after months of attacks and racial taunts.


They were the sort of family you might like to have as neighbors: The husband and wife are law enforcement officers; they have two well-mannered sons.






And the Orange County city of Yorba Linda is the sort you might like to live in, where the median income is $115,000 a year and almost half the adults have college degrees.


That's what made the episode so outrageous — but not, it turns out, an anomaly.


Rusty Kennedy tracks hate crimes as head of Orange County's Human Relations Commission. Black people make up only 2% of the county's residents, "but they are the most frequently targeted victims, year after year after year," he said.


"There are stories like what we imagine would be [taking place] in the Deep South," he said. "Many of our black families in Orange County are suffering."


They may not all have their tires slashed, but they live with more subtle forms of discrimination that can, over time, hurt just as much.


The account of the Yorba Linda family hints at that hidden reality. That case hadn't shown up on the hate crime list because police treated it as mere vandalism.


"There are two perspectives of what happens to African American families in Orange County," said Kennedy. "What they perceive and what others think."


The commission wanted to hear those perceptions first-hand, so planned a series of "listening sessions" in several communities.


The first was hosted last month by Orange County's largest black congregation, Christ Our Redeemer AME, which meets in a rented hall in an Irvine industrial park. There was lots of talk from dignitaries — preachers, law enforcement officers, community leaders — about teaching tolerance, seeking justice, advocating for change.


Then the 200 or so black people formed small circles and shared stories of insult, indignation and pain.


Many involved problems with police: Betty's grandson was arrested for skateboarding in an empty parking lot. Ulysses was spread-eagled across the hood of his car on his way home from work at juvenile hall. A fellow new to Brea was stopped near his home by an officer who said "I haven't seen you around here before."


Jona Knight-Hall said she was pulled over three times in 2007 in her new Mercedes. "It was always something like 'Your passenger isn't wearing her seat belt properly.' " She seldom got stopped in her old car. "But you can't risk driving an expensive car. People look at you like 'What is she doing with that?' "


"I felt completely helpless," she said. She tried to file a complaint, alleging racial profiling. "But you can't do anything about it, because people pretend that it's all in your mind."


::


Some of those who turned out seemed to have made peace with the downside of the good life in the suburbs of Orange County.


"Some things you just have to blow off," said a well-dressed young man with a diamond stud in his ear. Orange County is, at least, "a good place to practice conflict resolution. "


But for others the pain seemed persistent and raw.






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The Lede Blog: Winter Brings Misery to Syria Refugees

For Syrian refugees in Zaatari refugee camp in Jordan, winter has brought bitter new hardship and at least one death.

More than 50,000 people are estimated to live in Zaatari camp, roughly one third of the nearly 150,000 Syrians who have sought refuge in Jordan from the 22-month long conflict gripping their country. As my colleagues have Rick Gladstone and Nick Cumming-Bruce reported, wind and rainy weather this week wrecked scores of refugee dwellings in Zaatari, where many tents flooded or collapsed. People were left shivering in the cold, and outrage soon boiled over in an angry riot that injured 11 people, over half of them aid workers from the charity group Save the Children. It was the latest in at least four violent episodes in recent weeks between refugees, aid workers and the police.

Video of the Zaatari camp on Monday, posted online by Syrian activists, showed an area almost as large as a football field covered in shallow, muddy water. Inside a soaked tent, a young boy told the cameraman that he and his family, including his injured father, “went to a neighbor’s tent because of the water.”

Tents in Zaatari refugee camp were flooded with shallow, muddy water on Monday.

The suffering in Zaatari was given a human face on Wednesday when an activist uploaded a moving video interview with a refugee in the camp named Khaled al-Hariri, an amputee who described the difficulty of getting proper medical care in the camp. According to the activist, Abushakraa Horanee, Mr. Hariri died on Tuesday night before the video was uploaded to Facebook and then copied to a Syrian activist YouTube channel. Mr. Horanee, the filmmaker, called Mr. Hariri, “the martyr of negligence and cold.”

Video of Khaled al-Zubi, a Syrian refugee in Jordan, accusing camp doctors of negligence.

In the video, Mr. Hariri, who lost a leg in Syria before fleeing to Jordan, said he suffered from a range of respiratory problems that went untreated by camp doctors. Mr. Hariri broke down crying as he explained his health problems and alleged negligence and poor treatment on the part of doctors in the camp, which is run by the United Nations. “I don’t even want my health to improve,” he said. “I want my brothers’ health, the people all around me, to improve.”

Describing his ill-health, Mr. Hariri said, “I have hoarseness, chest pain, and mucus. With my leg pain. Here my leg, all of it, is inflamed. My chest also, my chest is inflamed.”

When asked if he was given a medical diagnosis by camp doctors, Mr. Hariri responded:

Diagnosed? No one diagnosed me. I stayed here for three months and no doctor gave me a proper drug, no doctor told me ‘there is a drug for that’, no doctor gave me anything. I just want something that will give me some relief. I just want something to give me some relief, that’s all. Pain killers. They didn’t give me that. I don’t know, what can I do?

Asked how doctors in the camp hospital responded to his visit, he responded:

Their response? I would go at night from here to the emergency room and call on them and tell them ‘my brother, for God’s sake….’ I would tell the ambulance driver, ‘my brother, for God’s sake, I swear I can’t breathe. I need oxygen, I need oxygen.’ So the ambulance would arrive and they wouldn’t even pick me up themselves. My brother, the broken one, would pick me and my uncle. They would pick me up and put me in the ambulance. Is that okay?

I would go and sit there. I’d be wearing this track suit while it’s cold outside. I would ask ‘Where is the doctor for him to put me in a bed?’ And the doctor would say ‘there is no bed. You’re going to have to wait a bit for the patient to leave.’ ‘Doctor, I swear I’m very tired. At least give me oxygen, I want to breathe. I can’t breathe.’ I could not breath at all.

U.N. officials said that most dwellings in the camp withstood the recent rainfall and attributed tensions in Zaatari to a range of factors, including fear of worsening weather conditions and a surge of as many as 9,000 new residents in the last week. On Twitter, Unicef, the United Nations children’s agency, said the organization was fully focused on improving conditions in the camp.

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A Tale of 2 Strategies: The Twitter Genius of Chuck Grassley and Cory Booker






If you’re on Twitter and not following Sen. Chuck Grassley, you’re not using Twitter correctly.


The Iowa Republican is known for his colorful and personal Twitter feed. Take a gander: He personally tweets about everything from the History Channel to “Obamacare” to an incident in which he hit a deer with his car  (“assume dead”). Grassley’s tweets take us along for a ride, one that’s often riddled with spelling errors (which he has said is due to his distaste for typing and the iPhone’s auto-correct function).







Pres/Cong need 2work on Wash spending prob. No time 2waste b/4 Mar. Pres promised tax hike is done. Now he needs 2keep promise 4 less spend


— ChuckGrassley (@ChuckGrassley) January 4, 2013



Rained inIowa this weekend. Still 8 inches shortIowa still still listed dangerous drought pray For rain


— ChuckGrassley (@ChuckGrassley) December 17, 2012



Fred and I hit a deer on hiway 136 south of Dyersville. After I pulled fender rubbing on tire we continued to farm. Assume deer dead


— ChuckGrassley (@ChuckGrassley) October 26, 2012


Contrast Grassley’s tweets to another lawmaker known for his active and personal feed: Newark, N.J., Mayor Cory Booker. On Twitter, he’s part mayor, part celebrity. Booker tweets about city services and was widely praised for how he utilized the platform in the aftermath of superstorm Sandy to connect directly with residents. But then he’ll retweet someone who says she’s going to get a Cory Booker quote tattoo or someone who has a “political crush” on him. Sometimes, Booker tweets like a Kardashian.



Think so, call 9737334311. My people will tell u RT @hennybottle: Is the number to get downed wires removed same for all of essex county?


— Cory Booker (@CoryBooker) January 8, 2013



“Hey, Never Met U, Your tweet’s Crazy, I’ll DM My Number, So Call Me Maybe?” MT @ann_ralston: I have a non-sexual, political crush on you!


— Cory Booker (@CoryBooker) January 8, 2013



Wow. An honor I never quite imagined RT @rachelanncohen: deliberating between several Cory Booker quotes for my next tattoo.


— Cory Booker (@CoryBooker) January 8, 2013



I love you too! RT @alwoldegorgeous: I can actually say I am in love with @kimkardashian#girlcrush


— Kim Kardashian (@KimKardashian) December 12, 2012


Obviously, Booker is savvier with Twitter than Grassley, and he’s utilized the platform effectively, as he vies for statewide office. Booker’s a PR genius with social media. Grassley’s himself–typos, rants, and all. So while Booker probably doesn’t need to take Twitter lessons from the six-term senator, there’s something decidedly old school and earnest that’s kind of appealing about Grassley’s feed, something that would be nice to see in Booker’s feed, too.



Welcome to Twitter Pope Benedict. U will find it useful and interesting


— ChuckGrassley (@ChuckGrassley) December 3, 2012


CORRECTION: Grassley has served in the Senate for six terms.  An earlier version of the story incorrectly listed his tenure.


Social Media News Headlines – Yahoo! News





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Diem Brown Blogs About Learning to Be Open to Therapy

In her PEOPLE.com blog, Diem Brown, the Real World/Road Rules Challenge contestant diagnosed with ovarian cancer for the second time, opens up about her desire for a child and the ups and downs of cancer and fertility procedures.

I grew up an Army brat and lived in Germany from when I was six years old until I was about 10. During those years, my mom wanted to make sure we absorbed as much "culture" and history as we could, so she would make us do a family drive around Europe on Saturdays. We did trips to every single monument, battlefield and castle you can imagine – and no drive was too far.

This might sound like an amazing adventure, but being a kid crammed into the back seat of a small car, driving up windy mountain roads between your sister and screaming brother, trying to reach your "field" destination ... Well, it felt more like pure torture!

Every week when Saturday rolled around, I would throw the most obnoxious temper tantrum screaming, "History IS history, Mom! I don't care about stupid castles! It's old! It's done!" Yes, what a precious gem of a child I was, huh? My temper tantrums never worked, and I was always quickly scooped up and thrown in the back seat where I waited for the impending car-sick history lesson to begin.

Fast-forward to college: I ironically enrolled as a history and political science major. I became obsessed with history and kicked myself for not realizing how cool those forced "history trips" really were. So, yes ... I was wrong ... and I misjudged the situation.

That leads me to the topic of therapy. When my mom passed away while I was in college, I was told by friends countless times: "You should go see someone ...it really will help you."

Therapy? No Thanks!

Diem Brown Blogs About Learning to Be Open to Therapy| Celebrity Blog, Health, Diem Brown

Diem Brown

Scott Gries for People.com

I would ignore their suggestions, because why would I talk to someone just to bring to the surface the hurt, loss and pain I felt over losing my mom? I was certain therapy was great for other people, but that I was "all good." I thought to myself, "I'm Southern! I know I can just swallow it, bury my pain and try to push forward with a smile."

Years later came my first bout with cancer, and as I walked into the infusion center, the "welfare" lady started handing me packet after packet of resources. I remember her urging me to try this "group therapy" session for young adults with cancer.

I politely took the packet but thought, "No way in HELL am I going to do group therapy!" I had such a wall up against doing therapy – private or in a group – because I feared it would tear some invisible Band-Aid off and I wouldn't be able to stop the flow of the unearthed pain.

Fast-forward to this past November when I was the keynote speaker at the National Ovarian Cancer Coalition (NOCC) conference, where I was asked to lead a small group discussion among fellow ovarian cancer patients and survivors.

I was nervous because I had no idea how to lead a group in a discussion. There were about 30 women of all ages and I had butterflies in my stomach. But after getting the nervous butterflies out, magic happened.

I found out that there were over 175 years of survivorship in that room – one woman was in her fourth round with this disgusting ovarian cancer disease. I was blown away as people started sharing their experiences.

One woman described the first time she went out without a wig: She went to the grocery store around the time when the movie G.I. Jane was in theaters. In the check-out lane a woman behind her snickered, "Well I guess if Demi Moore is doing it, it must be cool." As this gorgeous woman told her story, I became so angry hearing her explain how the entire grocery line laughed at the snickering woman's comment.

Toward the end of her story, the "grandma" in our discussion room chimed in saying, "Honey, here is what I've said to people who make stupid comments." The "grandma" went on to share when some of her hair grew back in after chemo, she too ventured out without a wig and sure enough, a thoughtless comment was thrown at her in a disgusted sarcastic tone, "Wow! Well, aren't you just a cool rebel grandma with your head all shaved."

The sweet "grandma" said she calmly looked the stranger in the eye and said, "Well, aren't you lucky and blessed to have never gone through or have seen anyone you love go through chemo for cancer." She said as the word "chemo" escaped from her mouth, the look on the face of the person who made the ugly comment was priceless and she knew that that person would probably think twice before throwing out a judgmental comment again.

The whole room laughed and was so impressed with how this "grandma" took control of a situation at a time when she likely felt at her weakest.

Changing My Tune

After leaving the small group, I understood what great things could come out of group therapy, how much you can learn from others and what it means to have a support system of people who have been in your shoes.

So once again I was wrong to judge something as "not for me." And today as my doctor recently suggested, "I think you should go see one of our therapists," I'm not insulted or twisting his words to insinuate, "Wait what?! Why does my doctor think I'm crazy?!"

This time, I actually intend to use the psychologist referral card, thank my doctor for his suggestion and am excited to try the whole therapy thing out.

I think we all have judged certain things by saying, "That's just not for me." But by stepping out of our comfort zone, allowing ourselves to "give it a try" can only open us up for opportunities to become more enlightened, to grow and to heal.

So watch out future psychologist, you have on hell of a basket case coming your way! :)

Diem Brown Blogs About Learning to Be Open to Therapy| Celebrity Blog, Health, Diem Brown

Diem Brown

Scott Gries for People.com

Check back for updates every Thursday: Diem will be chronicling exclusively for PEOPLE.com her journey through fertility treatments, chemotherapy and her quest to educate others about ovarian health. You can also follow her on Twitter @DiemBrown.

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Flu season strikes early and, in some places, hard


NEW YORK (AP) — From the Rocky Mountains to New England, hospitals are swamped with people with flu symptoms. Some medical centers are turning away visitors or making them wear face masks, and one Pennsylvania hospital set up a tent outside its ER to deal with the feverish patients.


Flu season in the U.S. has struck early and, in many places, hard.


While flu normally doesn't blanket the country until late January or February, it is already widespread in more than 40 states, with about 30 of them reporting some major hot spots. On Thursday, health officials blamed the flu for the deaths of 20 children so far.


Whether this will be considered a bad season by the time it has run its course in the spring remains to be seen.


"Those of us with gray hair have seen worse," said Dr. William Schaffner, a flu expert at Vanderbilt University in Nashville.


The evidence so far points to a moderate season, Schaffner and others say. It looks bad in part because last year was unusually mild and because the main strain of influenza circulating this year tends to make people sicker and really lay them low.


David Smythe of New York City saw it happen to his 50-year-old girlfriend, who has been knocked out for about two weeks. "She's been in bed. She can't even get up," he said.


Also, the flu's early arrival coincided with spikes in a variety of other viruses, including a childhood malady that mimics flu and a new norovirus that causes vomiting and diarrhea, or what is commonly known as "stomach flu." So what people are calling the flu may, in fact, be something else.


"There may be more of an overlap than we normally see," said Dr. Joseph Bresee, who tracks the flu for the Centers for Disease Control and Prevention.


Most people don't undergo lab tests to confirm flu, and the symptoms are so similar that it can be hard to distinguish flu from other viruses, or even a cold. Over the holidays, 250 people were sickened at a Mormon missionary training center in Utah, but the culprit turned out to be a norovirus, not the flu.


Flu is a major contributor, though, to what's going on.


"I'd say 75 percent," said Dr. Dan Surdam, head of the emergency department at Cheyenne Regional Medical Center, Wyoming's largest hospital. The 17-bed emergency room saw its busiest day ever last week, with 166 visitors.


The early onslaught has resulted in a spike in hospitalizations. To deal with the influx and protect other patients from getting sick, hospitals are restricting visits from children, requiring family members to wear masks and banning anyone with flu symptoms from maternity wards.


One hospital in Allentown, Pa., set up a tent this week for a steady stream of patients with flu symptoms. But so far "what we're seeing is a typical flu season," said Terry Burger, director of infection control and prevention for the hospital, Lehigh Valley Hospital-Cedar Crest.


On Wednesday, Boston declared a public health emergency, with the city's hospitals counting about 1,500 emergency room visits since December by people with flu-like symptoms.


All the flu activity has led some to question whether this year's flu shot is working. While health officials are still analyzing the vaccine, early indications are that it's about 60 percent effective, which is in line with what's been seen in other years.


The vaccine is reformulated each year, based on experts' best guess of which strains of the virus will predominate. This year's vaccine is well-matched to what's going around. The government estimates that between a third and half of Americans have gotten the vaccine.


In New York City, 57-year-old Judith Quinones skipped getting a flu shot this season and suffered her worst case of flu-like illness in years. She was laid up for nearly a month with fever and body aches. "I just couldn't function," she said.


But her daughter got the vaccine. "And she got sick twice," Quinones said.


Europe is also suffering an early flu season, though a milder strain predominates there. Flu reports are up, too, in China, Japan, the West Bank, the Gaza Strip, Algeria and the Republic of Congo. Britain has seen a surge in cases of norovirus.


On average, about 24,000 Americans die each flu season, according to the CDC. That's an estimate — the agency does not keep a running tally of adult flu deaths each year, only for children. Some state health departments do keep count, and they've reported dozens of flu deaths so far.


Flu usually peaks in midwinter. Symptoms can include fever, cough, runny nose, head and body aches and fatigue. Some people also suffer vomiting and diarrhea, and some develop pneumonia or other severe complications.


Most people with flu have a mild illness and can help themselves and protect others by staying home and resting. But people with severe symptoms should see a doctor. They may be given antiviral drugs or other medications to ease symptoms.


Flu vaccinations are recommended for everyone 6 months or older. Of the 20 children killed by the flu this season, only two were fully vaccinated.


___


AP Medical Writer Maria Cheng in London contributed to this report.


___


Online:


CDC flu: http://www.cdc.gov/flu/index.htm


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Irvine City Council overhauls oversight, spending on Great Park









Capping a raucous eight-hour-plus meeting, the Irvine City Council early Wednesday voted to overhaul the oversight and spending on the beleaguered Orange County Great Park while authorizing an audit of the more than $220 million that so far has been spent on the ambitious project.


A newly elected City Council majority voted 3 to 2 to terminate contracts with two firms that had been paid a combined $1.1 million a year for consulting, lobbying, marketing and public relations. One of those firms — Forde & Mollrich public relations — has been paid $12.4 million since county voters approved the Great Park plan in 2002.


"We need to stop talking about building a Great Park and actually start building a Great Park," council member Jeff Lalloway said.





The council, by the same split vote, also changed the composition of the Great Park's board of directors, shedding four non-elected members and handing control to Irvine's five council members.


The actions mark a significant turning point in the decade-long effort to turn the former El Toro Marine base into a 1,447-acre municipal park with man-made canyons, rivers, forests and gardens that planners hoped would rival New York's Central Park.


The city hoped to finish and maintain the park for years to come with $1.4 billion in state redevelopment funds. But that money vanished last year as part of the cutbacks to deal with California's massive budget deficit.


"We've gone through $220 million, but where has it gone?" council member Christina Shea said of the project's initial funding from developers in exchange for the right to build around the site. "The fact of the matter is the money is almost gone. It can't be business as usual."


The council majority said the changes will bring accountability and efficiencies to a project that critics say has been larded with wasteful spending and no-bid contracts. For all that has been spent, only about 200 acres of the park has been developed and half of that is leased to farmers.


But council members Larry Agran and Beth Krom, who have steered the course of the project since its inception, voted against reconfiguring the Great Park's board of directors and canceling the contracts with the two firms.


Krom has called the move a "witch hunt" against her and Agran. Feuding between liberal and conservative factions on the council has long shaped Irvine politics.


"This is a power play," she said. "There's a new sheriff in town."


The council meeting stretched long into the night, with the final vote coming Wednesday at 1:34 a.m. Tensions were high in the packed chambers with cheering, clapping and heckling coming from the crowd.


At one point council member Lalloway lamented that he "couldn't hear himself think."


During public comments, newly elected Orange County Supervisor Todd Spitzer chastised the council for "fighting like schoolchildren." Earlier this week he said that if the Irvine's new council majority can't make progress on the Great Park, he would seek a ballot initiative to have the county take over.


And Spitzer angrily told Agran that his stewardship of the project had been a failure.


"You know what?" he said. "It's their vision now. You're in the minority."


mike.anton@latimes.com


rhea.mahbubani@latimes.com





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Venezuelan Court: Chávez Swearing-In Can Be Postponed



CARACAS, Venezuela (AP) — Venezuela's foreign minister is hosting a meeting with leaders from 19 Latin American and Caribbean nations.


Nicolas Maduro plans to discuss issues related to Petrocaribe, a pact that has boosted the South American nation's influence in the region.


Venezuela created Petrocaribe in 2005 to sell fuel to member countries at preferential terms and help finance oil infrastructure projects.


Visiting leaders and foreign ministers are expected to attend an event Thursday to show their support for President Hugo Chavez.


Chavez is currently in Cuba recovering from cancer-related surgery.


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Go Ahead, Keep Being Mean to Celebrities on Twitter






We realize there’s only so much time one can spend in a day watching new trailers, viral video clips, and shaky cell phone footage of people arguing on live television. This is why every day The Atlantic Wire highlights the videos that truly earn your five minutes (or less) of attention. Today:  


RELATED: The Honey Boo Boo Nature Special; Everyone’s Favorite Sleepwalking Mom






We usually don’t condone being an impolite jerk to anyone, especially on social media. But we kind of make an exception because, well, if everyone was nice to everyone all of a sudden, we’d run out of fun Jimmy Kimmel segments where celebrities read their tweets:


RELATED: Ai Weiwei’s ‘Gangnam Style’ Isn’t Bad


RELATED: So Which Boyfriend Is Taylor Swift Singing About Now?


Oh man, this giant squid is like the most famous sea creature celebrity of the moment. And yes, it’s way freakier in motion:


RELATED: Katie Holmes Goes Bust on Broadway


RELATED: Justin Bieber is Coming to Town


So fine, this is sort of bending the rules per se because this isn’t really a video-video. It’s the Game of Thrones introduction with beatboxing by the Stark children. 


And finally, here is one minute of a man singing all the songs involving the word “baby.” And in case you were wondering, yes, Justin Bieber is officially in the Baby Pantheon of Music. 


Social Media News Headlines – Yahoo! News





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Jillian Michaels: Why I Decided to Come Back to The Biggest Loser



Jillian Michaels is back with a vengeance!

The personal trainer, 38, is eager for people to watch her return to reality TV on The Biggest Loser's 14th season on NBC, focusing her attention on the show's overweight youth.

"There were a lot of reasons for why I decided to come back," Michaels told PEOPLE on Wednesday in Pasadena, Calif., during the Television Critics Association's winter tour, naming fellow trainer Bob Harper as part of her motivation.

"Taking on childhood obesity is really exciting because both of us do work individually. Bob works with the First Lady [and] I work with the Clinton Foundation to help make a difference."

Michaels – who left the hit show after its 11th season to focus on raising a family with her partner Heidi Rhoades – calls the series "a fan favorite," adding, "It's something I had greatly underestimated."

Explains the fitness expert, "A vehicle like The Biggest Loser, with that kind of exposure and those kind of resources behind you, allows you to really get a message out and make a dent ... I never hear the end of, 'Go back to The Biggest Loser.' "

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Retooling Pap test to spot more kinds of cancer


WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.


Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.


How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.


In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.


This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.


"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.


But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.


The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.


"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.


"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.


But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.


More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.


Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.


The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.


So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.


The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.


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